Volulyte 6% Adverse Reactions

The undesirable effects are defined as follows: Very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10, 000 to <1/1,000), very rare (<1/10,000), frequency not known (cannot be estimated from the available data).
Blood and lymphatic system disorders: Rare (in high doses): With the administration of hydroxyethyl starch disturbances of blood coagulation beyond dilution effects can occur depending on the dosage.
Immune system disorders: Rare: Medicinal products containing hydroxyethyl starch may lead to anaphylactic/anaphylactoid reactions (hypersensitivity, mild influenza-like symptoms, bradycardia, tachycardia, bronchospasm, non-cardiac pulmonary oedema). If a hypersensitivity reaction occurs, administration of the drug should be discontinued immediately and the appropriate treatment and supportive measures should be undertaken until symptoms have resolved.
Skin and subcutaneous tissue disorders: Common (dose dependent): Prolonged administration of high dosages of hydroxyethyl starch may cause pruritus (itching) which is a known undesirable effect of hydroxyethyl starches.
Investigations: Common (dose dependent): The concentration of serum amylase level can rise during administration of hydroxyethyl starch and can interfere with the diagnosis of pancreatitis. The elevated amylase is due to the formation of an enzyme-substrate complex of amylase and hydroxyethyl starch subject to slow elimination and must not be considered diagnostic of pancreatitis.
Common (dose dependent): At high dosages the dilution effects may result in a corresponding dilution of blood components such as coagulation factors and other plasma proteins and in a decrease of haematocrit.